Abstract 20: Syndrome of the Trephined: Functional Improvement After Reconstruction of Large Cranial Vault Defects
نویسندگان
چکیده
PURPOSE: The hypoxia-signaling pathway regulates endochondral ossification, and is critically important for proper modulation of inflammation, angiogenesis, and osteogenesis following trauma. Although hypoxia inducible factor-1α (Hif-1α) and hypoxia inducible factor-2α (Hif2α) are critical mediators of this pathway, the role of these factors in fracture healing remains unclear, particularly with regards to the regulation of inflammation after injury. In this study, we define the role of hypoxia signaling in fracture healing, with the ultimate goal of identifying novel pharmacologic targets to improve fracture healing in a targeted manner.
منابع مشابه
Abstract 21: Identifying New Mutations Of Fgfr1a After CRISPR/Cas9 Genome Editing
METHODS: Patients with large cranial vault defects (>50cm) were studied preoperatively and postoperatively (6 months) after cranial vault reconstruction using both: 1) Cognistat Active Form and 2) The FIM instrument (Functional Independence Measure) (n=35). Cranial vault reconstructive techniques varied from split cranial bone to alloplastic implants (PEEK) to titanium implants. Complications, ...
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